Lurasidone added to either lithium or valproate was found to be an effective treatment for bipolar depression, with a larger antidepressant effect observed when lurasidone was combined with lithium. There were no clinically meaningful differences in the safety or tolerability of lurasidone when used adjunctively with lithium or valproate.
Keyphrases
- bipolar disorder
- solid state
- placebo controlled
- major depressive disorder
- double blind
- depressive symptoms
- randomized controlled trial
- clinical trial
- study protocol
- liver failure
- stem cells
- sleep quality
- open label
- physical activity
- radiation therapy
- mesenchymal stem cells
- intensive care unit
- stress induced
- bone marrow
- rectal cancer
- replacement therapy