Endothelial DLL4 Is an Adipose Depot-Specific Fasting Sensor Regulating Fatty Acid Fluxes.
Alex AupetitPauline DecaunesChloé BellesElodie RiantJean GalitzkyCandice ChapoulyMargaux LaisnéRémy Flores-FloresBenoit ChaputKatell ViéJean-François ArnalAnne BouloumiéAnaïs BriotPublished in: Arteriosclerosis, thrombosis, and vascular biology (2023)
DLL4 is a major actor in the adaptive mechanisms of AT-EC to regulate lipid fluxes. It likely contributes to fat depot-dependent metabolism in response to energy transition states. AT-EC alteration with obesity may favor metabolic inflexibility and the development of cardiometabolic disorders.