Ischemic Preconditioning and Postconditioning Protect the Heart by Preserving the Mitochondrial Network.

Nur Izzah IsmailNathaly Anto MichelKhairunnisa Katwadi Mim-Mim LimTo-Kiu ChanAttaur Rahman Dachun Xu Sang-Ging Ong Derek J Hausenloy Sang-Bing Ong

Published in: BioMed research international (2022)

IPC and IPost-mediated upregulation of pro-fusion proteins (Mfn1 and Mfn2) and downregulation of pro-fission (Drp1) promote maintenance of the interconnected mitochondrial network, ultimately conferring cardioprotection against IRI.

Keyphrases

ischemia reperfusion injury
oxidative stress
cerebral ischemia
cell proliferation
anti inflammatory
signaling pathway
heart failure
poor prognosis
atrial fibrillation
subarachnoid hemorrhage
network analysis