Influenza A virus infection dysregulates the expression of microRNA-22 and its targets; CD147 and HDAC4, in epithelium of asthmatics.

Fatemeh MoheimaniJorinke KoopsTeresa WilliamsAndrew T ReidPhilip M HansbroPeter A WarkDarryl A Knight

Published in: Respiratory research (2018)

The different profile of miR-22 expression in differentiated epithelial cells from non-asthmatics may indicate a self-defense mechanism against aberrant epithelial responses through suppressing CD147 and HDAC4, which is compromised in epithelial cells of asthmatics.

Keyphrases

poor prognosis
long non coding rna
cell proliferation
histone deacetylase
binding protein
signaling pathway
nk cells
innate immune