Left atrial myocardial intrinsic function remodeling response to repair of primary mitral regurgitation.
Matteo LisiMatteo CameliGiulia Elena MandoliMaria Concetta PastoreFrancesca Maria RighiniFilippo FlamigniFlavio D'AscenziLuna CavigliMarta FocardiAndrea RubboliGianluca CampoSergio MondilloMichael Y HeneinPublished in: Echocardiography (Mount Kisco, N.Y.) (2022)
Severe mitral regurgitation (MR) is a common valve disease which is associated with high mortality, if only managed medically. MR produces chronic and progressive volume overload with left atrial (LA) and left ventricular (LV) dilatation and dysfunction, atrial fibrillation (AF) and eventually myocardial fibrosis, irrespective of ejection fraction (EF). Surgical correction (mitral valve repair) of MR removes the volume overload, hence unmasks pre-operative LV structure and function disturbances, including reduced EF and global longitudinal and circumferential strain, as well as LA volume and strain. This review aims at describing LA remodeling before and after surgical repair.
Keyphrases
- left atrial
- left ventricular
- aortic stenosis
- atrial fibrillation
- mitral valve
- ejection fraction
- catheter ablation
- hypertrophic cardiomyopathy
- heart failure
- contrast enhanced
- cardiac resynchronization therapy
- magnetic resonance
- acute myocardial infarction
- oral anticoagulants
- multiple sclerosis
- aortic valve
- direct oral anticoagulants
- transcatheter aortic valve replacement
- coronary artery disease
- cross sectional
- risk factors
- type diabetes
- venous thromboembolism