TRPM8 indicates poor prognosis in colorectal cancer patients and its pharmacological targeting reduces tumour growth in mice by inhibiting Wnt/β-catenin signalling.
Ester PaganoBarbara RomanoDonatella CiciaFabio Arturo IannottiTommaso VenneriGiuseppe LucarielloMaria Francesca NanìFabio CattaneoPaola De CiccoMaria D'ArmientoMarcello De LucaRuggiero LionettiStefania LamaPaola StiusoPietro ZoppoliGeppino FalcoSilvia MarchianòStefano FiorucciRaffaele CapassoVincenzo Di MarzoFrancesca BorrelliAngelo A IzzoPublished in: British journal of pharmacology (2022)
Human data provide valuable insights to propose TRPM8 as a prognostic marker with a negative predictive value for CRC patient survival. Animal experiments demonstrate TRPM8 involvement in colon cancer pathophysiology and its potential as a drug target for CRC.
Keyphrases
- poor prognosis
- long non coding rna
- cell proliferation
- endothelial cells
- stem cells
- case report
- signaling pathway
- electronic health record
- epithelial mesenchymal transition
- cancer therapy
- induced pluripotent stem cells
- big data
- high fat diet induced
- emergency department
- type diabetes
- adverse drug
- adipose tissue
- insulin resistance
- data analysis
- artificial intelligence