Noncoding RNAs within the HOX gene network in tumor pathogenesis and progression.
Gerardo BottiAnna De ChiaraMaurizio Di BonitoMargherita CerroneMaria Gabriella MalzoneFrancesca CollinaMonica CantilePublished in: Journal of cellular physiology (2018)
HOX genes are involved with normal development, cell identity, cell differentiation, cell metabolism, apoptosis, autophagy as well as with diseases such as tumor pathogenesis and progression. In particular, the genes belonging to HOX paralogous 13 seem to carry out a relevant role in both tumor development and disease progression. In recent years, several noncoding RNAs (ncRNA) sequences have been identified in HOX loci, including long noncoding RNA (lncRNA) and microRNA (miRNA), highly conserved during evolution. Many studies have shown that specific intergenic ncRNAs in HOX loci could directly modulate HOX genes expression in normal and pathological conditions. In the present review we attempt to describe the role of these ncRNAs, through the regulation of the HOX gene network, in normal cell biology, and, with particular emphasis, in diseases such as in cancer pathogenesis and progression.
Keyphrases
- genome wide
- long noncoding rna
- genome wide identification
- single cell
- cell therapy
- dna methylation
- cell death
- oxidative stress
- endoplasmic reticulum stress
- poor prognosis
- copy number
- genome wide analysis
- transcription factor
- stem cells
- young adults
- bioinformatics analysis
- cell proliferation
- papillary thyroid
- network analysis
- case control