Age- and BMI-Associated Expression of Angiogenic Factors in White Adipose Tissue of Children.
Niklas GaeblerBenedikt HaggenmüllerMelanie KapapaAlexandre SerraDaniel TewsJan-Bernd FunckeStephanie BrandtValentin IoannidisMichael SchönPeter MöllerKlaus-Michael DebatinMartin WabitschPamela Fischer-PosovszkyPublished in: International journal of molecular sciences (2019)
The growth of adipose tissue and its vasculature are tightly associated. Angiogenic factors have been linked to obesity, yet little is known about their expression during early childhood. To identify associations of angiogenic factors with characteristics on individual and tissue level, subcutaneous white adipose tissue samples were taken from 45 children aged 0-9 years undergoing elective surgery. We measured the expression of vascular endothelial growth factor A (VEFGA), fibroblast growth factor 1 and 2 (FGF1, FGF2), angiopoietin 1 and 2 (ANGPT1, ANGPT2), TEK receptor tyrosine kinase (TEK), and von Willebrand factor (VWF). In addition, we determined the mean adipocyte size in histologic tissue sections. We found positive correlations of age with FGF1 and FGF2 and a negative correlation with ANGPT2, with pronounced differences in the first two years of life. FGF1, FGF2, and ANGPT1 correlated positively with adipocyte size. Furthermore, we identified a correlation of ANGPT1 and TEK with body mass index-standard deviation score (BMI-SDS), a measure to define childhood obesity. Except for ANGPT2, all angiogenic factors correlated positively with the endothelial marker VWF. In sum, our findings suggest that differences related to BMI-SDS begin early in childhood, and the analyzed angiogenic factors possess distinct roles in adipose tissue biology.
Keyphrases
- adipose tissue
- insulin resistance
- body mass index
- tyrosine kinase
- vascular endothelial growth factor
- high fat diet
- poor prognosis
- young adults
- metabolic syndrome
- endothelial cells
- type diabetes
- binding protein
- patients undergoing
- acute coronary syndrome
- epidermal growth factor receptor
- coronary artery disease
- long non coding rna
- physical activity
- minimally invasive
- early life