P2X7 receptor activation impairs antitumour activity of natural killer cells.
Alberto Baroja-MazoAlejandro Peñín-FranchFernando Lucas-RuizCarlos de Torre-MinguelaCristina Alarcón-VilaTrinidad Hernández-CasellesPablo PelegrínPublished in: British journal of pharmacology (2022)
Our results show that P2X7 activation represents a new mechanism whereby NK cells may lose antitumour effectiveness, opening the possibility of generating modified NK cells lacking P2X7 but with improved antitumour capacity.