MiRNA-21a, miRNA-145, and miRNA-221 Expression and Their Correlations with WNT Proteins in Patients with Obstructive and Non-Obstructive Coronary Artery Disease.
Alfiya Oskarovna IusupovaNikolay Nikolaevich PakhtusovOlga Alexandrovna SlepovaYuriy Nikitich BelenkovElena Vitalievna PrivalovaIrina Vladimirovna BureEkaterina Alexandrovna VetchinkinaMarina Vyacheslavovna NemtsovaPublished in: International journal of molecular sciences (2023)
Activation of the canonical cascade of WNT-β-catenin prevailed in patients with obstructive CAD, whereas in the INOCA and control groups, the activity of the non-canonical pathway was higher. It can be assumed that miR-21a has a negative effect on the formation of atherosclerotic CAD. Alternatively, miR-145 could be involved in the development of coronary artery obstruction, presumably through the regulation of the WNT4 protein. A mathematical model with WNT3a and LRP6 as predictors allows for the prediction of the type of coronary artery lesion.
Keyphrases
- cell proliferation
- coronary artery
- coronary artery disease
- stem cells
- pulmonary artery
- long non coding rna
- poor prognosis
- long noncoding rna
- percutaneous coronary intervention
- cardiovascular events
- heart failure
- cardiovascular disease
- pulmonary hypertension
- atrial fibrillation
- amino acid
- transcatheter aortic valve replacement