Nature as a source and inspiration for human monoamine oxidase B (Hmao-B) inhibition: A review of the recent advances in chemical modification of natural compounds.

All the natural scaffolds herein presented displayed a broad chemical diversity. The knowledge of their biological activity as inhibitors of hMAO-B enzyme allows the positive correlations associated with the consumption of specific food or the possible herb-drug interactions and suggests to the Medicinal Chemists how to address chemical functionalization to obtain more potent and selective compounds.