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Nature as a source and inspiration for human monoamine oxidase B (Hmao-B) inhibition: A review of the recent advances in chemical modification of natural compounds.

Francesco MelfiSimone CarradoriAndrea AgeliIlaria D'Agostino
Published in: Expert opinion on drug discovery (2023)
All the natural scaffolds herein presented displayed a broad chemical diversity. The knowledge of their biological activity as inhibitors of hMAO-B enzyme allows the positive correlations associated with the consumption of specific food or the possible herb-drug interactions and suggests to the Medicinal Chemists how to address chemical functionalization to obtain more potent and selective compounds.
Keyphrases
  • endothelial cells
  • healthcare
  • anti inflammatory
  • tissue engineering
  • human health