Catalytic C-H alkynylation of benzylamines and aldehydes with aldimine-directing groups generated in situ .

Iridium-catalysed regioselective C-H alkynylation of unprotected primary benzylamines and aliphatic aldehydes has been achieved using in situ-installed aldimine directing groups. This protocol provides a straightforward route for the synthesis of the alkynylated primary benzylamine and aliphatic aldehyde derivatives, featuring good substrate compatibility and high regioselectivity.