The effect of metformin on biomarkers associated with breast cancer outcomes: a systematic review, meta-analysis, and dose-response of randomized clinical trials.

J RahmaniN ManzariJ ThompsonS K GudiM ChhabraG NaikS M MousaviH K VarkanehC ClarkYong Zhang

Published in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2019)

Breast cancer patients receiving metformin as treatment for diabetes showed significant reduction in levels of insulin, fasting glucose, CRP, HOMA, leptin, BMI, and Ki-67.

Keyphrases

type diabetes
glycemic control
systematic review
blood glucose
cardiovascular disease
meta analyses
insulin resistance
neoadjuvant chemotherapy
randomized controlled trial
metabolic syndrome
adipose tissue
breast cancer risk
squamous cell carcinoma
young adults
case control
skeletal muscle
locally advanced