Indobufen alleviates ischemic stroke injury by regulating transcription factor NRF2 and inhibiting ATG5 expression.

Yang WangGe BaiShanshan MuFenglian ZhangYan Wang

Published in: The Journal of pharmacy and pharmacology (2024)

IND could inhibit autophagy, oxidative stress, and apoptosis in SH-SY5Y cells with OGD/R exposure, further alleviating IS injury by regulating transcription factor NRF2 and inhibiting ATG5 expression.

Keyphrases

oxidative stress
induced apoptosis
transcription factor
poor prognosis
signaling pathway
cell cycle arrest
endoplasmic reticulum stress
cell death
diabetic rats
dna damage
ischemia reperfusion injury
dna binding
binding protein
atrial fibrillation
long non coding rna
pi k akt
mouse model