A subset of microRNAs in the Dlk1-Dio3 cluster regulates age-associated muscle atrophy by targeting Atrogin-1.
Yeo Jin ShinEun-Soo KwonSeung-Min LeeSeon-Kyu KimKyung-Won MinJae-Young LimBora LeeJae Sook KangJu Yeon KwakYoung Hoon SonJeong Yi ChoiYong Ryul YangSeokho KimYeon-Soo KimHak C JangYousin SuhJe-Hyun YoonKwang-Pyo LeeKi-Sun KwonPublished in: Journal of cachexia, sarcopenia and muscle (2020)
Our study suggests that genetic intervention using a muscle-directed miRNA delivery system has therapeutic efficacy in preventing Atrogin-1-mediated muscle atrophy in sarcopenia.