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Increased Expression of CXCL6 in Secretory Cells Drives Fibroblast Collagen Synthesis and is Associated With Increased Mortality in Idiopathic Pulmonary Fibrosis.

Harinath BahudhanapatiJiangning TanRosa Marie ApelBenjamin SeeligerJonas Christian SchuppXiaoyun LiDaniel I SullivanJohn SembratMauricio RojasTracy TabibEleanor ValenziRobert A LafyatisNilay MitashRicardo H PinedaChetan JawaleDoureradjou PeroumalPartha BiswasJohn TedrowTaylor Sterling AdamsNaftali KaminskiWim A WuytsJohn F McDyerKevin F GibsonJonathan K AlderMelanie KönigshoffYingze ZhangSeyed Mehdi NouraieAntje PrasseDaniel J Kass
Published in: The European respiratory journal (2023)
CXCL6 is expressed in ectopic airway epithelial cells. Elevated levels of CXCL6 are associated with IPF mortality. CXCL6-driven collagen synthesis represents a functional consequence of ectopic localization of airway epithelial cells in IPF.
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