Dysregulated Expression and Methylation Analysis Identified TLX1NB as a Novel Recurrence Marker in Low-Grade Gliomas.
Hongzhou DuanZuozhen YangChen LiJiayong ZhangShengli ShenChangwei YuanYingjin WangPublished in: International journal of genomics (2020)
Low-grade gliomas (LGGs) are the most common CNS tumors, and the main therapy for LGGs is complete surgical resection, due to its curative effect. However, LGG recurrence occurs frequently. Biomarkers play a crucial role in evaluating the recurrence and prognosis of LGGs. Numerous studies have focused on LGG prognosis. However, the multiomics research investigating the roles played by gene methylation and expression in LGG recurrence remains limited. In this study, we integrated the TCGA and GEO datasets, analyzing RNA and methylation data for recurrence (R) and nonrecurrence (NR) groups. We found a low expression of TLX1NB and high methylation in recurrence patients. Low expression of TLX1NB is associated with poor survival (OS: p = 0.04). The expression of TLX1NB is likely to play a role in the prognosis of LGG. Therefore, TLX1NB may represent an alternative early biomarker for the recurrence of low-grade gliomas.
Keyphrases
- low grade
- high grade
- poor prognosis
- free survival
- genome wide
- dna methylation
- binding protein
- end stage renal disease
- long non coding rna
- chronic kidney disease
- gene expression
- ejection fraction
- electronic health record
- newly diagnosed
- transcription factor
- artificial intelligence
- data analysis
- genome wide identification