Sulindac plus a phospholipid is effective for polyp reduction and safer than sulindac alone in a mouse model of colorectal cancer development.

Jennifer S DavisPreeti Kanikarla-MarieMihai GageaPatrick L YuDexing FangManu SebastianPeiying YangErnest HawkRoderick DashwoodLenard M LichtenbergerDavid MenterScott Kopetz

Published in: BMC cancer (2020)

Together these data provide pre-clinical support for combining NSAIDs with a phospholipid, such as phosphatidylcholine to reduce GI toxicity while maintaining chemopreventive efficacy.

Keyphrases

mouse model
fatty acid
electronic health record
oxidative stress
big data
machine learning
anti inflammatory drugs
deep learning