Asparaginyl endopeptidase contributes to cetuximab resistance via MEK/ERK signaling in RAS wide-type metastatic colorectal cancer.

Xiaojing XuMengling LiuKe PengYiyi YuTian-Shu Liu

Published in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2023)

The higher expression of AEP could contribute to the shorter PFS of cetuximab treatment in mCRC. The reason might be that AEP could promote the phosphorylation of MEK/ERK protein in the downstream signal pathway of EGFR.

Keyphrases

metastatic colorectal cancer
pi k akt
signaling pathway
cell proliferation
small cell lung cancer
poor prognosis
wild type
binding protein
epidermal growth factor receptor
tyrosine kinase
protein kinase
squamous cell carcinoma
radiation therapy
combination therapy
replacement therapy