Stage-specific regulation of signalling pathways to differentiate pluripotent stem cells to cardiomyocytes with ventricular lineage.

Ramakanth SatthenapalliScott LeeJayanthi Bellae PapannaraoTimothy A HoreAkash ChakrabortyPeter P JonesRegis R LambertsRajesh G Katare

Published in: Stem cell research & therapy (2022)

Our results provide the first evidence of in vitro differentiation that mimics the embryonic morphogenesis towards ventricular specific cardiomyocytes through regulation of Wnt and RA signalling pathways.

Keyphrases

pluripotent stem cells
heart failure
left ventricular
rheumatoid arthritis
stem cells
catheter ablation
high glucose
single cell
ankylosing spondylitis
endothelial cells
interstitial lung disease
cell fate