Epidemiologic studies show since 1980, non-HDL-C levels of individuals has increased rapidly in Asian countries.The study has suggested that vascular risk factors increase the risk of VaD, such as disordered lipid metabolism. Dyslipidemia has been found to interact with chronic cerebral hypoperfusion to promote inflammation resulting in cognitive dysfunction in the brain.Hypercholesterolemia may be a risk factor for VaD. Inflammation could potentially serve as a link between hypercholesterolemia and VaD. Additionally, the potential impact of lipid-lowering therapy on cognitive function is also worth considering. Finding strategies to prevent and treat VaD is critical given the aging of the population to lessen the load on society. Currently, controlling underlying vascular risk factors is considered one of the most effective methods of preventing VaD. Understanding the relationship between abnormal cholesterol levels and VaD, as well as discovering potential serum biomarkers, is important for the early prevention and treatment of VaD.
Keyphrases
- risk factors
- low density lipoprotein
- oxidative stress
- cardiovascular events
- cognitive impairment
- fatty acid
- type diabetes
- stem cells
- white matter
- mild cognitive impairment
- cardiovascular disease
- mesenchymal stem cells
- multiple sclerosis
- bone marrow
- risk assessment
- blood brain barrier
- cerebral ischemia
- combination therapy
- smoking cessation