Serum from Acute-on-chronic Liver Failure Patients May Affect Mesenchymal Stem Cells Transplantation by Impairing the Immunosuppressive Function of Cells.
Yongyuan ZhengShu ZhuXingrong ZhengWenxiong XuXuejun LiJianguo LiZhiliang GaoChan XieLiang PengPublished in: Journal of clinical and translational hepatology (2021)
The 50% ACLF serum concentration is more similar to the environment in the human body, which means that direct peripheral blood intravenous infusion of MSCs may reduce the effect of transplantation. Combining treatments of plasma exchange to reduce harmful substances in serum may promote MSCs to exert a stronger anti-inflammatory effect.
Keyphrases
- liver failure
- mesenchymal stem cells
- umbilical cord
- peripheral blood
- hepatitis b virus
- end stage renal disease
- anti inflammatory
- cell therapy
- ejection fraction
- endothelial cells
- induced apoptosis
- newly diagnosed
- chronic kidney disease
- bone marrow
- prognostic factors
- peritoneal dialysis
- drinking water
- oxidative stress
- intensive care unit
- pluripotent stem cells
- respiratory failure
- endoplasmic reticulum stress
- patient reported