Production of recombinant humanized monoclonal anti-human neutrophil antigen (HNA) antibodies with potential applicability as standard antibodies.
Yuko IshimotoKikuyo TaniguchiBehnaz BayatRyutaro TobitaToru MiyazakiRie OnoderaEmi KuritaMasao KobayashiKazuo MuroiNelson-Hirokazu TsunoPublished in: Transfusion (2023)
These are the first humanized monoclonal antibodies to HNA-1 and HNA-2 antigens produced and they will be important standard reagents for laboratories testing for neutrophil antibodies. We plan to have these humanized MoAbs available through WHO.