A Cu(OTf) 2 -Catalyzed Glycosylation with Glycosyl ortho - N -Phthalimidoylpropynyl Benzoates as Donors.

A Cu(OTf) 2 -catalyzed glycosylation protocol using glycosyl ortho - N -phthalimidoylpropynyl benzoates (NPPBs) as donors was disclosed, which features an inexpensive copper catalyst, operationally convenient conditions, high to excellent yields, and a broad substrate scope. Mechanistic studies indicated an isochromen-4-yl copper(II) intermediate arising from the departure of the leaving group.