Platinum Nanoparticles: The Potential Antioxidant in the Human Lung Cancer Cells.

Oxidative stress-related conditions associated with lung cells, specifically lung cancer, often lead to a poor prognosis. We hypothesized that platinum nanoparticles (PtNPs) can play a role in reversing oxidative stress in human lung adenocarcinoma A549 epithelial lung cell lines. Hydrogen peroxide (H 2 O 2 ) was used to induce oxidative stress in cells, and the ability of PtNPs to lower the oxidative stress in the H 2 O 2 treated epithelial lung cell line was determined. The differential capacity of PtNPs to remove H 2 O 2 was studied through cell viability, nanoparticle uptake, DNA damage, ROS production, and antioxidant enzymes (superoxide dismutase, glutathione peroxidase, and catalase). Results indicated that a higher concentration of PtNPs exhibited a higher antioxidant capacity and was able to reduce DNA damage and quench ROS production in the presence of 350 µM H 2 O 2 . All antioxidant enzymes' activities also increased in the PtNPs treatment. Our data suggested that PtNPs could be a promising antioxidant in the treatment of lung cancer.