Randomised controlled trial of two sequential artemisinin-based combination therapy regimens to treat uncomplicated falciparum malaria in African children: a protocol to investigate safety, efficacy and adherence.
Henk Dfh SchalligHalidou TintoPatrick SawaHarparkash KaurStephan DuparcDeus S IshengomaPascal MagnussenMichael AlifrangisColin J SutherlandPublished in: BMJ global health (2017)
This protocol addresses efficacy and safety of sequential ACT regimens in P. falciparum malaria in Africa. The approach is designed to extend the useful life of this class of antimalarials with maximal impact and minimal delay, by deploying licensed medicines that could be swiftly implemented as sequential double ACT by National Malaria Control Programmes, before emerging drug resistance in Africa becomes a major threat to public health.