Differential Expression of Vascular-Related MicroRNA in Circulating Endothelial Microvesicles in Adults With Spinal Cord Injury: A Pilot Study.

Andrew J ParkHannah K FandlVinicius P GarciaGeoff B CoombsNoah M DeSouzaJared J GreinerOtto F BarakTanja MijacikaZeljko DujicPhilip N AinslieChristopher A DeSouza

Published in: Topics in spinal cord injury rehabilitation (2023)

This study is the first examination of EMV miRNA cargo in adults with SCI. The cargo signature of vascular-related miRNAs studied reflects a pathogenic EMV phenotype prone to induce inflammation, atherosclerosis, and vascular dysfunction. EMVs and their miRNA cargo represent a novel biomarker of vascular risk and a potential target for intervention to alleviate vascular-related disease after SCI.

Keyphrases

spinal cord injury
oxidative stress
randomized controlled trial
cardiovascular disease
endothelial cells
risk assessment
human health
drug induced