Dehydrogenative β-Arylation of Saturated Aldehydes Using Transient Directing Groups.
Xing-Long ZhangGao-Fei PanXue-Qing ZhuRui-Li GuoYa-Ru GaoYong-Qiang WangPublished in: Organic letters (2019)
An unprecedented cross-dehydrogenative-coupling (CDC) reaction of saturated aldehyde β-C-H with arenes to form cinnamaldehydes via the cleavages of four C-H bonds has been developed. The reaction possesses complete E-stereoselectivity for the C═C double bond. The protocol is featured by atom and step economy, mild reaction conditions, and convenient operation.