Noradrenergic control of neurobehavior in human binge-eating disorder and obesity (NOBEAD): A smartphone-supported behavioral emotion regulation intervention study protocol integrating molecular brain imaging.
Swen HesseMichael RullmannFranziska ZientekDanielle ScheweGeorg-Alexander BeckerMarianne PattPhilipp M MeyerAdrienne S JuarascioGuido K W FrankOsama SabriAnja HilbertPublished in: The International journal of eating disorders (2023)
This study investigates the central noradrenaline system by using hybrid brain imaging in conjunction with emotion regulation as a putative core biological mechanism in individuals with obesity with or without binge-eating disorder that is targeted by emotion regulation intervention. The results will provide a molecular signature beyond functional imaging biomarkers as a predictive biomarker toward precision medicine for tailoring treatments for individuals with binge-eating disorders and obesity.
Keyphrases
- physical activity
- randomized controlled trial
- insulin resistance
- high resolution
- metabolic syndrome
- weight loss
- type diabetes
- study protocol
- high fat diet induced
- weight gain
- white matter
- resting state
- clinical trial
- functional connectivity
- skeletal muscle
- mass spectrometry
- blood brain barrier
- open label
- photodynamic therapy