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Immunohistopathological characterization and the impact of topical immunomodulatory therapy in oral chronic graft-versus-host disease: A pilot study.

Ana Carolina Fragoso MottaQ ZhanA LarsonM LermanS-B WooR J SoifferG F MurphyN S Treister
Published in: Oral diseases (2018)
The high expression of CD3, CD4, CD8, CD103, CD163, and FoxP3 confirms that oral cGVHD is largely T-cell-driven with macrophage participation. The impact of topical immunomodulatory therapy was variable, reducing histological inflammatory features, but with a weak clinicopathological correlation. Topical dexamethasone reduced the expression of CD4 and CD103, which may offer novel therapeutic targets.
Keyphrases
  • poor prognosis
  • wound healing
  • nk cells
  • physical activity
  • oxidative stress
  • adipose tissue
  • regulatory t cells
  • stem cells
  • binding protein
  • long non coding rna
  • high dose