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[Expression and Significance of PD-1/PD-L1 in MDS Blast Cells, T Lymphocyte Cell Subsets and Treg Cells].

Yue-Fei WangBao-Guo ChenRui ZhengYi-Ni Yu
Published in: Zhongguo shi yan xue ye xue za zhi (2024)
The high expression of PD-1/PD-L1, dominance of Treg (IL-10、TGF-β) and Th2-related cytokines and inhibition of effector T lymphocyte cells in patients with MDS is conducive to tumor cell proliferation and immune escape, which may promote the progression of MDS disease.
Keyphrases
  • induced apoptosis
  • cell cycle arrest
  • cell proliferation
  • poor prognosis
  • cell death
  • stem cells
  • signaling pathway
  • cell cycle
  • dendritic cells
  • immune response
  • bone marrow
  • regulatory t cells