Pyrin Inflammasome Activation Abrogates Interleukin-1 Receptor Antagonist, Suggesting a New Mechanism Underlying Familial Mediterranean Fever Pathogenesis.
Sussi B MortensenAnn-Brit E HansenTrine Hyrup MogensenMarianne A JakobsenHans C BeckEva B HarvaldKate L LambertsenIsik S JohansenDitte Caroline AndersenPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2021)
Our data show an inherent lack of IL-1Ra expression specific to pyrin inflammasome activation, suggesting a new mechanism underlying FMF pathogenesis. The reduced IL-1Ra levels in FMF monocytes suggest a diminished antiinflammatory capacity that potentially leaves FMF patients sensitive to proinflammatory stimuli, regardless of receiving colchicine therapy. Thus, considering the potential clinical consequence of reduced monocyte IL-1Ra secretion in FMF patients, we suggest further investigation into IL-1Ra dynamics and its potential implications for FMF treatment in the future.
Keyphrases
- end stage renal disease
- rheumatoid arthritis
- ejection fraction
- newly diagnosed
- chronic kidney disease
- prognostic factors
- disease activity
- ankylosing spondylitis
- peritoneal dialysis
- dendritic cells
- poor prognosis
- stem cells
- machine learning
- big data
- immune response
- peripheral blood
- mesenchymal stem cells
- risk assessment
- systemic sclerosis
- cell therapy
- electronic health record
- deep learning
- idiopathic pulmonary fibrosis
- binding protein
- patient reported
- combination therapy
- artificial intelligence
- replacement therapy
- essential oil