Gp130 is expressed in pancreatic cancer and can be targeted by the small inhibitor molecule SC144.

Christian Hans Wolfgang SchineisNina A HeringEmily GuenzlerMarco ArndtSefer ElezkurtajThomas KnöselChristiane J BrunsGeorgios A MargonisKatharina BeyerHendrik Seeliger

Published in: Journal of cancer research and clinical oncology (2022)

Gp130 is expressed in the epithelium of most human PDAC, but stromal expression is rare. The small molecule gp130 inhibitor SC144 potently inhibits PDAC progression in vitro and may abrogate IL-6 or OSM/gp130/STAT3 signaling. These results suggest gp130 as a novel drug target for pancreatic cancer therapy.

Keyphrases

cancer therapy
small molecule
endothelial cells
poor prognosis
drug delivery
bone marrow
cell proliferation
emergency department