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15-Deoxy-Δ12,14-prostaglandin J2 Upregulates the Expression of 15-Hydroxyprostaglandin Dehydrogenase by Inducing AP-1 Activation and Heme Oxygenase-1 Expression in Human Colon Cancer Cells.

Jong-Min ParkHye-Kyung Na
Published in: Journal of cancer prevention (2019)
These finding suggest that 15d-PGJ2 upregulates the expression of 15-PGDH through AP-1 activation in colon cancer HCT116 cells.
Keyphrases
  • poor prognosis
  • cell cycle arrest
  • transcription factor
  • endothelial cells
  • induced apoptosis
  • oxidative stress
  • cell death
  • signaling pathway