Hypoxia-induced TMTC3 expression in esophageal squamous cell carcinoma potentiates tumor angiogenesis through Rho GTPase/STAT3/VEGFA pathway.

Hongyu YuanZitong ZhaoJing XuRuiping ZhangLiying MaJing HanWeihong ZhaoMingzhou GuoYongmei Song

Published in: Journal of experimental & clinical cancer research : CR (2023)

Collectively, our study clarified the molecular mechanism of TMTC3 in regulating tumor angiogenesis and highlighted the potential therapeutic combination of TMTC3 inhibitor and cisplatin, which proposed a promising strategy for the treatment of ESCC.

Keyphrases

endothelial cells
vascular endothelial growth factor
poor prognosis
cell proliferation
wound healing
combination therapy
long non coding rna
smooth muscle
smoking cessation