Cytotoxic activity and molecular targets of atractylodin in cholangiocarcinoma cells.

Vivek B MathemaWanna ChaijaroenkulKesara Na-Bangchang

Published in: The Journal of pharmacy and pharmacology (2018)

Atractylodin exerts significant cytotoxic activity against CL-6 cells which may be linked to its suppressive effect on HO-1 production, STAT1/3 phosphorylation and expression of key NF-κB proteins.

Keyphrases

induced apoptosis
cell cycle arrest
signaling pathway
pi k akt
poor prognosis
oxidative stress
cell proliferation
endoplasmic reticulum stress
lps induced
immune response
binding protein