Markers of vitamin B12 status in relation to cerebrospinal fluid biomarkers of Alzheimer's disease and cognitive performance.

Markers of vitamin B12 may be independent predictors of CSF biomarkers of Alzheimer's disease and cognitive functioning, with methyl malonic acid showing the most consistent effects. Randomized controlled trials are needed to determine the importance of vitamin B12 supplementation on slowing structural brain changes and cognitive decline. This article is protected by copyright. All rights reserved.