Methodological Challenges in Randomized Controlled Trials on Smartphone-Based Treatment in Psychiatry: Systematic Review.
Morten Lindbjerg TønningLars Vedel KessingJakob Eyvind BardramMaria Faurholt-JepsenPublished in: Journal of medical Internet research (2019)
This first systematic review of the methodological challenges in designing and conducting RCTs investigating smartphone-based treatment in psychiatric patients suggests an increasing number of trials but with a lower quality compared with classic medical RCTs. Heterogeneity and methodological issues in individual trials limit the evidence. Methodological recommendations are presented.