Altered synaptic ultrastructure in the prefrontal cortex of Shank3-deficient rats.

Sarah Jacot-DescombesNeha U KeshavDara L DicksteinBridget WicinskiWilliam G M JanssenLiam L HiesterEdward K SarfoTahia WardaMatthew M FamHala Harony-NicolasJoseph D BuxbaumPatrick R HofMerina Varghese

Published in: Molecular autism (2020)

We observed increased HD and PSD area in Shank3-Het rats. These observations suggest the occurrence of altered synaptic ultrastructure in this animal model, further pointing to a key role of defective expression of the Shank3 protein in ASD and Phelan-McDermid syndrome.

Keyphrases

prefrontal cortex
autism spectrum disorder
poor prognosis
risk assessment
binding protein
attention deficit hyperactivity disorder
case report
electron microscopy
long non coding rna
working memory