A transcriptomic analysis of serial-cultured, tonsil-derived mesenchymal stem cells reveals decreased integrin α3 protein as a potential biomarker of senescent cells.

Da Hyeon ChoiSe-Young OhJu Kwang ChoiKyeong Eun LeeJu Yeon LeeYoon Jeong ParkInho JoYoon Shin Park

Published in: Stem cell research & therapy (2020)

Our data suggest that activation of ECM-receptor signaling, specifically involved with integrin family-mediated activation of the intracellular cell survival-signaling molecule AKT, can regulate stem cell senescence in TMSCs. Among these identified factors, ITGA3 was found to be a representative biomarker of the senescent TMSCs. Exclusion of the TMSCs with the senescent TMSC markers in this study could potentially increase the therapeutic efficacy of TMSCs in clinical applications.

Keyphrases

stem cells
induced apoptosis
endothelial cells
signaling pathway
cell cycle arrest
cell proliferation
electronic health record
cell migration
cross sectional
cell adhesion
cell death
reactive oxygen species
oxidative stress
extracellular matrix
cell therapy