Defective FGFR1 Signaling Disrupts Glucose Regulation: Evidence From Humans With FGFR1 Mutations.

Maria I StamouCrystal J ChiuShreya V JadhavVanessa Ferreira LopesKathryn B SalnikovLacey PlummerMargaret F LippincottHang LeeStephanie B SeminaraRavikumar Balasubramanian

Published in: Journal of the Endocrine Society (2024)

These findings suggest that impaired FGFR1 signaling may contribute to an early insulin resistance phase of diabetes pathogenesis and support the candidacy of the FGFR1 signaling pathway as a therapeutic target for improving the human metabolic health.

Keyphrases

insulin resistance
signaling pathway
type diabetes
endothelial cells
healthcare
cardiovascular disease
public health
metabolic syndrome
high fat diet
pi k akt
blood pressure
polycystic ovary syndrome
skeletal muscle
pluripotent stem cells
endoplasmic reticulum stress
weight loss
social media
human health