The Role of Brain Derived Neurotrophic Factor in HIV-Associated Neurocognitive Disorder: From the Bench-Top to the Bedside.
Henry Ukachukwu MichaelThabisile MpofanaSuvira RamlallFrasia OosthuizenPublished in: Neuropsychiatric disease and treatment (2020)
Human immunodeficiency virus (HIV)-associated neurocognitive disorder (HAND) remains prevalent in the anti-retroviral (ART) era. While there is a complex interplay of many factors in the neuropathogenesis of HAND, decreased neurotrophic synthesis has been shown to contribute to synaptic degeneration which is a hallmark of HAND neuropathology. Brain derived neurotrophic factor (BDNF) is the most abundant and synaptic-promoting neurotrophic factor in the brain and plays a critical role in both learning and memory. Reduced BDNF levels can worsen neurocognitive impairment in HIV-positive individuals across several domains. In this paper, we review the evidence from pre-clinical and clinical studies showing the neuroprotective roles of BDNF against viral proteins, effect on co-morbid mental health disorders, altered human microbiome and ART in HAND management. Potential applications of BDNF modulation in pharmacotherapeutic, cognitive and behavioral interventions in HAND are also discussed. Finally, research gaps and future research direction are identified with the aim of helping researchers to direct efforts to make these BDNF driven interventions improve the quality of life of patients living with HAND.
Keyphrases
- antiretroviral therapy
- hiv positive
- human immunodeficiency virus
- hiv infected
- men who have sex with men
- hiv aids
- hepatitis c virus
- mental health
- south africa
- stress induced
- hiv testing
- ejection fraction
- newly diagnosed
- physical activity
- end stage renal disease
- sars cov
- prognostic factors
- multiple sclerosis
- white matter
- cerebral ischemia
- bariatric surgery
- mental illness
- risk assessment
- brain injury
- weight loss
- pluripotent stem cells
- prefrontal cortex