Proteomics identifies differences in fibrotic potential of extracellular vesicles from human tendon and muscle fibroblasts.
Ching-Yan Chloé YeungErwin M SchoofMichal TamášAbigail L MackeyMichael KjaerPublished in: Cell communication and signaling : CCS (2020)
Our data demonstrates a marked heterogeneity among healthy fibroblast-derived EVs, indicating shared tasks between EVs of skeletal muscle myoblasts and fibroblasts, whereas tendon fibroblast EVs could play a fibrotic role in human tendon tissue. These findings suggest an important role for EVs in tissue homeostasis of both tendon and skeletal muscle in humans. Video abstract.
Keyphrases
- skeletal muscle
- anterior cruciate ligament reconstruction
- endothelial cells
- rotator cuff
- insulin resistance
- systemic sclerosis
- induced pluripotent stem cells
- idiopathic pulmonary fibrosis
- pluripotent stem cells
- mass spectrometry
- type diabetes
- working memory
- electronic health record
- extracellular matrix
- big data
- dna methylation
- deep learning