Effects of sulfur dioxide, ozone, and ambient air pollution on lung histopathology, oxidative-stress biomarkers, and apoptosis-related gene expressions in rats.
Sorayya KheirouriDariush ShanehbandiMonireh KhordadmehrMohammad AlizadehFateme Eskandari VaeziRazieh Musapour Sultan AbadMehran Mesgari AbbasiPublished in: Experimental lung research (2022)
The results indicated induction of oxidative stress. Our results suggest the apoptosis stimuli effect of AAP and also the extrinsic apoptotic pathway trigger effect of sulfur dioxide and ozone in the lung tissue in the concentrations used in the present study. The histopathological and the genes expression changes may be a result of the induced oxidative stress in the lung tissues.
Keyphrases
- oxidative stress
- air pollution
- particulate matter
- hydrogen peroxide
- cell death
- dna damage
- diabetic rats
- endoplasmic reticulum stress
- induced apoptosis
- ischemia reperfusion injury
- cell cycle arrest
- genome wide
- poor prognosis
- genome wide identification
- lung function
- nitric oxide
- anti inflammatory
- signaling pathway
- cell proliferation
- copy number
- dna methylation
- pi k akt
- binding protein