Gracillin Isolated from Reineckia carnea Induces Apoptosis of A549 Cells via the Mitochondrial Pathway.

Jianqiong YangLing CaoYamei LiHai LiuMinhong ZhangHuamou MaBiao WangXiaoliang YuanQian Liu

Published in: Drug design, development and therapy (2021)

This study confirmed that gracillin has a significant antiproliferative effect on A549 cells. Gracillin could induce the apoptosis of A549 cells through the mitochondrial pathway, which might be associated with regulation of the concentration of intracellular calcium, the mitochondrial membrane potential and the expression levels of Bax, Bcl-2, caspase-3, cleaved caspase-3, and cytochrome C.

Keyphrases

induced apoptosis
cell cycle arrest
oxidative stress
endoplasmic reticulum stress
cell death
signaling pathway
pi k akt
poor prognosis
climate change
risk assessment