Time to prerandomization seizure count design sufficiently assessed the safety and tolerability of perampanel for the treatment of primary generalized tonic-clonic seizures.

Wesley T KerrLeock Y NgoLiang ZhuAnna PattenJocelyn Y ChengAdvith S ReddyJacqueline A French

Published in: Epilepsia (2024)

Almost all TEAEs occurred before T-PSC. More treatment-related TEAEs occurred after T-PSC for participants randomized to placebo than perampanel, which may be due to either a shorter T-PSC or delayed time to TEAE for placebo.

Keyphrases

double blind
placebo controlled
open label
phase iii
clinical trial
randomized controlled trial
combination therapy
peripheral blood
smoking cessation