Circulating extracellular vesicles as biomarker for diagnosis, prognosis, and monitoring in glioblastoma patients.
Franz L RicklefsKathrin WollmannAmanda Salviano-SilvaRichard DrexlerCecile L MaireMichael G KaulRudolph ReimerUlrich SchüllerSarina HeinemannKatharina KolbeTobias MummertMarkus GlatzelSven PeineBernhard MeyerManfred WestphalLasse DührsenKatrin LamszusPublished in: Neuro-oncology (2024)
Our findings suggest that leakiness of the blood-brain barrier may primarily be responsible for the high circulating EV concentrations in glioblastoma patients. Elevated EVs reflect tumor presence, and their quantification may thus be valuable in assessing disease activity.