MPEP Lowers Binge Drinking in Male and Female C57BL/6 Mice: Relationship with mGlu5/Homer2/Erk2 Signaling.

Gan Huang Summer L ThompsonJane R Taylor

Published in: Alcoholism, clinical and experimental research (2021)

MPEP reduced alcohol consumption during DID in male and female C57BL/6 mice but did not change Homer2/Erk2 expression. Locomotor activity did not mediate the effects of MPEP on alcohol intake, though it correlated with alcohol intake. Alcohol intake during DID predicted BNST Homer2 expression. These data provide support for the regulation of alcohol consumption by mGlu5 across sexes.

Keyphrases

alcohol consumption
poor prognosis
signaling pathway
high fat diet induced
cell proliferation
pi k akt
spinal cord injury
type diabetes
insulin resistance
wild type
machine learning
adipose tissue