Jo-1 Antibodies From Myositis Induce Complement-Dependent Cytotoxicity and TREM-1 Upregulation in Muscle Endothelial Cells.

Masaya HondaFumitaka ShimizuRyota SatoYoichi MizukamiKenji WatanabeYukio TakeshitaToshihiko MaedaMichiaki KogaTakashi Kanda

Published in: Neurology(R) neuroimmunology & neuroinflammation (2023)

Jo-1 antibodies from Jo-1 antibody myositis show complement-dependent cellular cytotoxicity in muscle endothelial cells. IgGs from patients with Jo-1, SRP, and DM increase the TREM-1 expression in endothelial cells and muscles.

Keyphrases

endothelial cells
poor prognosis
high glucose
skeletal muscle
interstitial lung disease
vascular endothelial growth factor
cell proliferation
long non coding rna
systemic sclerosis
type diabetes
myasthenia gravis
insulin resistance
adipose tissue