Dynamic interplay between corticosteroid treatment and the role of SRC-1 gene dysregulation in the progression of WHO-Grade 4 Astrocytoma.

Maher KurdiMotaz M FadulBassam M J AddasEyad FaizoShadi AlkhayyatAhmed K BamagaTaghreed AlsinaniYousef KatibFahad OkalYazid MaghrabiAbdulrahman J SabbaghRana MoshrefSultan AlbalawiAlaa AlkhotaniTaher F HalawaNasser MullaSahar HakamySaleh Baeesa

Published in: Journal of neuro-oncology (2023)

Corticosteroid treatment can directly affect the SRC-1 gene regulation but does not directly influence cytotoxic T-cells infiltration or tumor progression. However, SRC-1 gene downregulation can facilitate late tumor recurrence.

Keyphrases

tyrosine kinase
genome wide
copy number
cell proliferation
poor prognosis
gene expression